Pragmatic Approaches to Precise Problems

High Yield/Impactful Articles


Study Design

Understanding RCTs

How to Read a Meta-Analysis


Sedation

Daily interruption of sedation

SLEAP

MIND-USA

NONSEDA

MENDS-2

AID-ICU (2023)


Stroke

DAWN

DESTINY (hemicrani)

RESCUE Japan


Resuscitation after Cardiac Arrest

HACA

TTM

TTM2

HYPERION

CAPITAL CHILL

ARREST

Tracheal intubation and survival

INCEPTION


Postop CT Surgery and Mechanical Circulatory Support

MOMENTUM 3

Rate vs rhythm control for a.fib. after cardiac surgery

VANCS

ADVOR

DanGer Shock


Resuscitation/Sepsis

Goal-directed sepsis resuscitation

EGDT (Rivers et al)

PROCESS

ProMISe

ARISE


MAP Targets/Vasopressor Strategies

SEPSISPAM

65 trial

ANDROMEDA-SHOCK

VASST

Association Between US Norepinephrine Shortage and Mortality


IV Fluid Volume Management

FEAST

Low vs high volume meta-analysis

CLASSIC

CLOVERS


IV Fluid Choice

SAFE

SMART

CRISTAL

ALBIOS

HES vs. saline


Adjunct Shock Therapy: Steroids, HAT, Vitamin C

Original Annane trial

CORTICUS

ADRENAL

APROCCHSS

VITAMINS

LOVIT (Vitamin C)

Evaluation of Etomidate use and association with mortality compared with ketamine among critically ill patients


Respiratory support/ARDS Care

Lung-protective Ventilation

ARMA

ALVEOLI

EPVent-2

PROSEVA

ACURASYS

ROSE

LUNG SAFE


VV ECMO

CESAR

EOLIA

Bayesian analysis of EOLIA


Weaning and Post-extubation Care

TRAC MAN

Postextubation HFNC/NIV

TEAM

FAST


Oxygenation Targets

HOT-ICU

Oxygen-ICU

ICU ROX

BOX

PILOT


Nutrition/GI

TARGET

PERMIT

EPANIC

EDEN

Supplementary parenteral nutrition trial

SUP-ICU

PEPTIC


Renal Failure and Dialysis

AKIKI

SMARRT-AKI

IDEAL-ICU

RENAL

AKIKI2

PLUS


Transfusion

TRICS III

FOCUS

TRISS

Transfusion strategies in upper GI bleeding

REALITY

PROPPR


Endocrine

NICE SUGAR


Infectious Disease

STOP-IT

MERINO

PROGRESS


Palliative Care

RCT of family-support intervention in ICUs


Healthcare Disparities in Critical Illness

Association of Race and Ethnicity with COVID-19 Test Positivity and Hospitalization Is Mediated by Socioeconomic Factors

Racial bias in pulse oximetry

Patient and Hospital Factors Associated With Differences in Mortality Rates Among Black and White US Medicare Beneficiaries Hospitalized With COVID-19 Infection

Temporal Trends in Critical Care Outcomes in U.S. Minority-Serving Hospitals

Racial Variation in End-of-Life Intensive Care Use: A Race or Hospital Effect?

Genetic misdiagnoses and the potential for health disparities